Protein Details: Aquaporin TIP1-1

Protein ID

ICDB_Pro_0436

Protein Name

Aquaporin TIP1-1

Gene Name

TIP1-1; AQP.1; At2g36830; T1J8.1

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

251 amino acids

AlphaFoldDB

AF-P25818-F1-model_v4.pdb

Function

Water channel required to facilitate the transport of water; diffusion of amino acids and/or peptides from the vacuolar compartment to the cytoplasm. Does not promote glycerol permeability. May play a role in the control of cell turgor and cell expansion. Its function is impaired by Hg(2+). May be involved in a vesicle-based metabolite routing through or between pre-vacuolar compartments and the central vacuole. Transports urea in yeast cells in a pH-independent manner. Transports H(2)O(2) in yeast cells.

Sequence

MPIRNIAIGRPDEATRPDALKAALAEFISTLIFVVAGSGSGMAFNKLTENGATTPSGLVAAAVAHAFGLFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLILKFATGGLAVPAFGLSAGVGVLNAFVFEIVMTFGLVYTVYATAIDPKNGSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLVGGGIAGLIYEVFFINTTHEQLPTTDY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

In all the vegetative organs; but not in seeds; Preferentially expressed in roots.

DOI ID

10.1093/nar/18.24.7449; 10.1104/pp.99.2.561; 10.1007/bf00023557; 10.1038/45471; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1046/j.1365-313x.1993.04061051.x; 10.1046/j.1365-313x.1996.09010101.x; 10.1002/j.1460-2075.1993.tb05877.x; 10.1105/tpc.8.4.587; 10.1186/gb-2001-3-1-research0001; 10.1104/pp.103.027409; 10.1111/j.1365-313x.2004.02265.x; 10.1099/vir.0.82252-0; 10.1074/jbc.m603761200

RefSeq

NP_181221.1